Dwarfism, hypopituitarism, and growth hormone.
نویسندگان
چکیده
منابع مشابه
Dwarfism, hypopituitarism, and growth hormone.
Small stature or growth retardation is a frequent problem in children, often leading to serious psychological repercussions. In some patients, as for instance in those with achondroplasia, severe hypothyroidism, or classical Turner's syndrome, the underlying disorder can easily be recognized. More often the growth retarded child presents no other symptoms, and the cause of dwarfism remains obsc...
متن کاملPhenotypic correction of dwarfism by constitutive expression of growth hormone.
GH is normally secreted in a pulsatile fashion. When GH is deficient, dwarfism is the result in both rodents and humans. An adenoviral vector containing the rat GH complementary DNA was used to induce constitutive GH expression in hepatocytes of GH-deficient lit/lit mice. Elevated serum GH increased circulating insulin-like growth factor I concentrations, corrected the growth deficiency, and no...
متن کاملDefining growth hormone status in adults with hypopituitarism.
The identification of adults with severe growth hormone (GH) deficiency (GHD) is not straightforward. The insulin tolerance test remains the gold standard diagnostic test, although other stimuli such as GH-releasing hormone-arginine are gaining acceptance. Insulin-like growth factor-I has a poor diagnostic sensitivity in adult-onset GHD, but is more useful in the subgroup of adults with childho...
متن کاملA novel missense mutation in the mouse growth hormone gene causes semidominant dwarfism, hyperghrelinemia, and obesity.
The SMA1-mouse is a novel ethyl-nitroso-urea (ENU)-induced mouse mutant that carries an a-->g missense mutation in exon 5 of the GH gene, which translates to a D167G amino acid exchange in the mature protein. Mice carrying the mutation are characterized by dwarfism, predominantly due to the reduction (sma1/+) or absence (sma1/sma1) of the GH-mediated peripubertal growth spurt, with sma1/+ mice ...
متن کامل[Somatomedin (bioassay) response to long-term growth hormone treatment of idiopathic pituitary dwarfism].
Serum somatomedin (SM) activity by bioassay was measured in 46 idiopathic pituitary dwarfs before and during long-term hGH treatment. The mean (+/- SD) pretreatment SM activity was 0.38 +/- 0.17 U/ml. The mean (+/- SD) pretreatment annual growth rate was 3.4 +/- 1.0 cm/year. None of the patients had a SM activity within the normal range of age-matched controls. The mean SM activity 1 day post G...
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood
سال: 1967
ISSN: 0003-9888,1468-2044
DOI: 10.1136/adc.42.223.225